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Nonhemopoietic Cell TLR4 Signaling Is Critical in Causing Early Lipopolysaccharide-Induced Ileus
Journal of Immunology, 11/09/09
Buchholz BM et al. – Hemopoietic and nonhemopoietic cells contribute to TLR4–sensitive muscularis inflammatory signaling, but nonhemopoietic TLR4 signaling plays an exclusive primary role in causing functional UP–LPS–induced gastric stasis and ileus. Direct LPS suppression of spontaneous contractility participates in mediating early TLR4–transduced dysmotility.
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