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Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia
Annals of Internal Medicine, 11/03/09

Sharma M et al. – This review of 102 studies found 2 trials that suggested lower target lipid levels were more often achieved with statin–ezetimibe combination therapy than with high–dose statin monotherapy. No firm trial evidence showed that combining a statin with another agent (bile–acid sequestrant, fibrate, ezetimibe, niacin, or omega–3 fatty acids) improved clinical outcomes (myocardial infarction, stroke, or mortality) more often than high–dose statin monotherapy.

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Monotherapy versus combination therapy for the treatment of chronic hepatitis B
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Disparate Response to Metoclopramide Therapy for Gastric Feeding Intolerance in Trauma Patients With and Without Traumatic Brain Injury
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Boehringer Ingelheim, 10/20/09 Relevance Score: 81%

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Gilead Sciences Announces Plans for Phase IV Clinical Trial Evaluating First-Line Combination Therapy Versus Monotherapy in Pulmonary Arterial Hypertension
Gilead, 11/03/09 Relevance Score: 80%