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See Latest ArticlesDoes rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
Arthritis Care and Research , 11/03/09
Peters MJL et al. – The risk of CVD in RA was significantly elevated compared with the general population, and comparable with the magnitude of risk in type 2 DM.
Methods- 3-year incidence rate of CVD determined in prospective cohort (the Cardiovascular Research and Rheumatoid Arthritis Study) of 353 outpatients with RA, and compared with that in 1,852 population-based cohort study participants (155 had type 2 DM)
- Investigated fatal and nonfatal CVD (according to International Classification of Diseases, Ninth Revision criteria) and used Cox proportional hazards models to assess incidence of CVD in RA, type 2 DM, and general population
- 3-year incidence of CVD 9.0% in patients with RA and 4.3% in general population, corresponding with incidence rate of 3.30 per 100 patient-years (95% confidence interval [95% CI] 2.08-4.25) and 1.51 per 100 person-years (95% CI 1.18-1.84), respectively
- Compared with general population, the age- and sex-adjusted hazard ratio (HR) for RA was 1.94 (95% CI 1.24-3.05)
- Neither exclusion of patients with prior CVD at baseline nor adjustment for cardiovascular risk factors significantly influenced this
- Compared with the nondiabetic population, nondiabetic patients with RA and those with type 2 DM had comparable HRs, 2.16 (95% CI 1.28-3.63) and 2.04 (95% CI 1.12-3.67), respectively
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