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Cartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study
Arthritis Care and Research , 11/05/09

Neogi T et al. SBA is strongly associated with cartilage loss within the same subregion of a knee. SBA may directly influence overlying cartilage loss or serve as a marker of an area undergoing great compressive stress and in which cartilage loss is inevitable.

• Multicenter Osteoarthritis Study is cohort of individuals who have or are at high risk for knee OA
• At baseline and 30 months, participants' knee MRIs graded using the Whole-Organ Magnetic Resonance Imaging Score in 10 subregions of the tibiofemoral joint for cartilage morphology and SBA
• Analyses conducted within a knee to eliminate between-person confounding, using an M:N (cases:controls) matched case-control approach with 10 subregions of person's knee forming matched set
• Cases within a knee were defined as subregions with cartilage loss, while controls were subregions in that same knee without cartilage loss
• Evaluated the association of cartilage loss over 30 months with presence of baseline SBA in same subregion within that knee using conditional logistic regression

• SBA associated with odds ratio of 7.5 (95% confidence interval 5.6-9.9) for cartilage loss in same subregion compared with subregions without any baseline SBA in sample of 459 knees
• 64% women, mean age 63 y
• Mean BMI of 30.5 kg/m2

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