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The Assessment of Glycemic Variability and Its Impact on Diabetes-Related Complications: An Overview
Diabetes Technology & Therapeutics, 10/30/09

Weber C et al. – There is a growing body of evidence that the sole use of hemoglobin A1c is insufficient to adequately reflect the metabolic situation of patients with diabetes mellitus. The risk of developing diabetes–related complications apparently not only depends on the long–term stability of glucose values, but also on the presence or occurrence of short–term glycemic peaks and nadirs lasting for minutes or hours during a day. This leads to the phenomenon of glycemic variability. This article reviews the existing evidence for the clinical relevance of short–term glucose variations and the currently available different means of measuring glycemic variability.

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