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Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention
American Journal of Clinical Nutrition, 10/29/09
Bo S et al. – Lifestyle modifications improved the metabolic pattern in all genetic subgroups. At the end of the trial, however, weight gain occurred, and carriers of the T allele developed first hyperglycemia and decreased insulin secretion, which suggests the need for different "after–care" preventive approaches tailored to each genotype’s metabolic risk.
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