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See Latest ArticlesLoss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1
Human Molecular Genetics, 11/03/09
Zhou J et al. – Disruption of Pten, an upstream regulator of TSC1/TSC2, in the same cells, does not lead to PKD seemingly due to limited activation of mTORC1, suggesting that PTEN may not be a major upstream regulator of TSC/mTORC1 during early postnatal kidney development.
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