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See Latest ArticlesFollow-up results of 702 patients receiving tumor necrosis factor-alpha antagonists and evaluation of risk of tuberculosis
Rheumatology International, 10/29/09
Cagatay T et al. – Diagnostic accuracy of TST for detecting latent tuberculosis is high among patients with inflammatory diseases even in the setting of immunosuppression. The risk of development of active TB is increased in this group of patients despite chemoprophylaxis, but this risk remains within the acceptable limits even in a moderate-tuberculosis incidence country, if proper chemoprophylaxis regimen is adhered.
Methods- 702 patients with different inflammatory diseases receiving TNF-&alpha antagonists followed up from August 2005 to July 2008 at our department of chest disease
- All patients had tuberculin skin test (TST) and postero-anterior chest radiograph (CXR) prior to anti TNF-&alpha antagonist treatment
- All patients with TST result ≥ 5 mm or fibrotic lesions on CXR were administered chemoprophylaxis with isoniazid (INH) for 9 months
- 6 patients developed active tuberculosis (4 pulmonary and 2 extrapulmonary) during follow-up period
- TST found positive in 434 (61.8%) of patients
- Patients, who were already on immunosuppressive therapy and who were not, were compared for difference in their TST results and no statistically significant difference was found
- Chemoprophylaxis administered overall to 583 (83.0%) patients among which 31 (5.3%) developed hepatotoxicity
- Of patients who developed active tuberculosis, all were decided to receive INH chemoprophylaxis
Today in Clinical Pharmacology...keeping you current
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Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome
Diabetes Care, 11/25/09
Low-Density Lipoprotein Cholesterol Reduction and Goal Achievement With Ezetimibe/Simvastatin Versus Atorvastatin or Rosuvastatin in Patients With Diabetes, Metabolic Syndrome, or Neither Disease, Stratified By National Cholesterol Education Program Risk Category
Metabolic Syndrome and Related Disorders, 11/25/09
Chronic Obstructive Pulmonary Disease: Role of Bacteria and Updated Guide to Antibacterial Selection in the Older Patient
Drugs & Aging, 11/25/09
Today in General Medicine...keeping you current
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Chronic Obstructive Pulmonary Disease: Role of Bacteria and Updated Guide to Antibacterial Selection in the Older Patient
Drugs & Aging, 11/25/09
Primary Care Providers Views of Challenges and Rewards of Dementia Care Relative to Other Conditions
Journal of the American Geriatrics Society, 11/25/09
Addition of cilostazol reduces biological aspirin resistance in aspirin users with ischaemic stroke: a double-blind randomized clinical trial
European Journal of Neurology, 11/25/09
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