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Breastfeeding modulates the influence of the peroxisome proliferator-activated receptor gamma (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: the HELENA Cross-Sectional Study
Diabetes Care, 11/05/09
Verier C et al. – The peroxisome proliferator–activated receptor gamma 2 (PPARG2) Pro12Ala polymorphism has been associated with a higher body mass index (BMI) and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors like early growth, dietary fat and (as recently shown) breastfeeding. Breastfeeding appears to counter the deleterious effect of the PPARG2Pro12Ala polymorphism on anthropometric parameters in adolescents.
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