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From asthma severity to control: a shift in clinical practice
Primary Care Respiratory Journal, 10/19/09

Pedersen S – New international guidelines recommend control–driven management rather than management based on disease severity. Good asthma control is associated with reductions in patients’ perception of the asthma burden, reduced healthcare resource utilisation, lower levels of impairment/restriction, normal quality of life, and low risk of exacerbations. Asthma control involves the control of several outcomes. Its assessment should include components relevant to achievement of best possible clinical control and reduction of future risk of adverse outcomes. Focusing on a single or a few outcomes can lead to incorrect control assessment and increased risk of under–treatment. Several validated asthma control assessment tools have been developed to facilitate correct assessment of the level of control in clinical practice. It is hoped that focusing on control will reduce the frequency of sub–optimal treatment in the primary care setting. Further validation of the best way to assess control easily and accurately, and the implementation of control–driven management, are the two most important challenges for the future of asthma management.

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Clinical importance of identifying immunoglobulin E-mediated disease in patients with Asthma
Clinical Cornerstone, 10/01/09 Relevance Score: 96%

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma
Osteoporosis International, 10/13/09 Relevance Score: 95%

The Saudi Initiative for asthma
Annals of Thoracic Medicine, 10/13/09 Relevance Score: 95%

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, 10/09/09 Relevance Score: 95%

Identification of Asthma Phenotypes using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine, 11/09/09 Relevance Score: 94%