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In utero exposure to therapeutic radiation for Hodgkin lymphoma
Canadian Family Physician, 10/14/09

Klieger–Grossmann C et al. – Congenital anomalies and growth impairment have been reported in infants and adolescents exposed in utero to radiation; however, most studies show that delayed growth and malformations occur following high doses of ionizing radiation, mostly greater than 50 cGy. Thus, radiotherapy should not be an absolute contraindication in pregnant patients diagnosed with cancer located remote from the pelvic area (eg, breast cancer, brain tumours, head and neck tumours, and supradiaphragmatic tumours). In such cases, the fetal radiation dose and the predictive effects should be estimated by qualified medical personnel (ie, a radiation physicist or radiation oncologist) and discussed with the woman (or the couple) on an individual basis to allow an optimally informed decision. Close prenatal follow–up of structural abnormalities, as well as of fetal growth and neurodevelopment, is indicated in these cases.

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