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Folic acid fortification: a double-edged sword
Current Opinion in Clinical Nutrition & Metabolic Care, 10/14/09

Lucock M et al. – There is a consensus view that folic acid supplementation has numerous health benefits, many of which are significant in their impact. However, emerging evidence suggests that increased population exposure to folic acid may also have a negative impact with respect to certain developmental and degenerative disorders. As examples, presently much attention is focused on the role of folic acid fortification augmenting colon cancer risk, whereas earlier in the life cycle, the vitamin may additionally influence insulin resistance...The highly complex and critical biological importance of folic acid–related molecular nutrition makes it a difficult micronutrient to deploy as a simple intervention at a population level – it has far too many biochemical spheres of influence to predict effects in a generalized way. Additionally, several gene variants and other nutrients are interactive factors. It is, therefore, hardly surprising that the scientific community does not have a true consensus view on whether mandatory fortification is appropriate as a population measure.

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