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See Latest ArticlesModulation of Neuropathic Pain by a Glial-Derived Factor
Pain Medicine, 10/14/09
Adler JE et al. – Intrathecal application of GDNF stimulates expression of somatostatin, a neuropeptide with potential analgesic properties. Moreover, stimulation of dorsal root sensory neurons with GDNF in vitro increases cell content of somatostatin, which, in turn, leads to increased secretion in response to depolarizing stimuli. The authors suggest that GDNF exerts its anti–allodynic effect via somatostatinergic mechanisms. These observations suggest new approaches for treating nerve injury that may prove useful in preventing delayed complications that contribute to long–term debility.
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