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Atherosclerosis describes any hardening and loss of elasticity of the arteries due to a build–up of fatty material such as cholesterol. Activation of the complement system, which consists of a cascade of small proteins that can result in cell lysis or trigger inflammation, plays a regulatory role in atherosclerotic lesion development. However, whereas proximal members of the complement pathway have a protective role, distal components are atherogenic.

   

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