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See Latest ArticlesAcute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives
Current Opinion in Oncology, 10/14/09
Falini B et al. – Nucleophosmin (NPM1) gene mutations, which cause aberrant cytoplasmic expression of nucleophosmin (NPMc+), are the most frequent genetic alteration in acute myeloid leukemia (AML), being found in about 30% cases. The present review summarizes recent advances in the biology, diagnosis, prognosis and therapy of NPM1–mutated AML. AML with mutated NPM1 is a leukemia entity with distinct molecular, pathological, and prognostic features.
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