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Effect of nonsteroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: a randomized controlled trial
Modern Rheumatology, 10/12/09

Doi T et al. – The objective of this study was to examine the effect of a nonsteroidal anti-inflammatory drug (NSAID) plaster for knee osteoarthritis among Japanese patients. It was found that the local application of a plaster with NSAIDs leads to the same level of improvement in knee osteoarthritis as oral NSAIDs.

Methods

Open-labeled, randomized, controlled, multiclinic trial
Outpatient clinic groups
2 comparative groups—plaster NSAIDs and oral NSAIDs—randomly allocated
Drugs used limited to current top 3 in both groups in Japan
Treatments assessed after 4 weeks and compared with baseline scores

Results

Outcomes evaluated by 2 psychometric measures: Japanese knee osteoarthritis measure, and pain with visual analogue scale
Total number of patients included in final evaluation was 165 (87 for plaster group and 78 for oral group)
No significant differences in gender, age, body height and weight, BMI, and X-ray grading
Subjects in both groups showed improvements in both scores at end of intervention
Differences in improvements in scores between the 2 groups were not significant, though mean rank score and 95% CI of plaster group were slightly better than those of oral group

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