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See Latest ArticlesSystems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients
Journal of Clinical Rheumatology (JCR), 10/12/09
van Wietmarschen H et al. – RA patients could be divided in 2 groups according to CM theory. Molecular differences between the RA Cold and RA Heat groups were found which suggest differences in apoptotic activity. Subgrouping of patients according to CM diagnosis has the potential to provide opportunities for better treatment outcomes by targeting Western or CM treatment to specific groups of patients
Methods- Blood samples of 33 RA patients and 16 healthy volunteers collected
- RA patients diagnosed according to Chinese medicine (CM) theory and divided into 2 groups, the RA Heat and RA Cold group
- CD4+ T-cells were used for a total gene expression analysis
- Metabolite profiles measured in plasma using gas chromatography/mass spectrometry
- Multivariate statistics employed to find potential biomarkers for the RA Heat and RA Cold phenotype
- Comprehensive biologic interpretation of results is discussed
- Genomics and metabolomics analysis showed statistically relevant different gene expression and metabolite profiles between healthy controls and RA patients as well as between the RA Heat and RA Cold group
- Differences found in regulation of apoptosis
- In RA Heat group caspase 8 activated apoptosis seems stimulated while in RA Cold group apoptosis seems suppressed through the Nrf2 pathway
Today in Complementary Medicine...keeping you current
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Functional Scores and Subjective Responses of Injured Workers With Back or Neck Pain Treated With Chiropractic Care in an Integrative Program: A Retrospective Analysis of 100 Cases
Journal of Manipulative and Physiological Therapeutics, 12/14/09
Acute Low Back Pain with Radiculopathy: A Double-Blind, Randomized, Placebo-Controlled Study
Photomedicine and Laser Surgery, 12/14/09
Efficacy of Traditional Chinese Medicine for the Management of Constipation: A Systematic Review
Journal of Alternative and Complementary Medicine, 12/14/09
Today in General Medicine...keeping you current
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Resolution of ST-segment depression: a new prognostic marker in ST-segment elevation myocardial infarction
European Heart Journal, 12/14/09
Association of Increased QTc Interval With the Cardiometabolic Syndrome
The Journal of Clinical Hypertension, 12/14/09
Effect of Obesity on Platelet Reactivity and Response to Low-Dose Aspirin
Preventive Cardiology, 12/14/09
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