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The Safety of Sumatriptan and Naratriptan in Pregnancy: What Have We Learned?
Headache: The Journal of Head and Face Pain, 10/07/09

Cunnington M et al. – The risk of all major birth defects following first–trimester exposure to sumatriptan was 4.6% (95% CI 2.9–7.2%). This coupled with a consistent failure of additional epidemiological studies to observe a signal for major teratogenicity gives a level of reassurance concerning the safety of sumatriptan in pregnancy. There are too few data on naratriptan to draw definitive conclusions, and the sample size for sumatriptan remains too small to detect any but very large increases in specific birth defects.

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