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Maternal Licorice Consumption and Detrimental Cognitive and Psychiatric Outcomes in Children
American Journal of Epidemiology, 10/06/09
Raikkonen et al. – In comparison to the group with zero–low glycyrrhiza exposure (0–249 mg/week), those with high exposure (>=500 mg/week) had significant decrements in verbal and visuospatial abilities and in narrative memory and significant increases in externalizing symptoms and in attention, rule–breaking, and aggression problems. The effects on cognitive performance appeared dose related. Data are compatible with adverse fetal "programming" by overexposure to glucocorticoids and caution against excessive intake of licorice–containing foodstuffs during pregnancy.
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