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See Latest ArticlesLongitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus
Atherosclerosis, 10/08/09
de Leeuw K et al. – The age-related increase in IMT is higher in SLE, indicating that atherosclerosis is accelerated in SLE patients. This is mainly due to disease-related risk factors, as disease duration was independently associated with IMT.
Methods- 74 SLE patients, age ranging from 13 to 69 years, and 74 age- and sex-matched controls included
- IMT of common carotid artery determined by B-mode ultrasound imaging
- Traditional risk factors for atherosclerosis and disease-related factors recorded
- Cardiovascular risk estimated using systematic coronary risk evaluation (SCORE)
- Markers of inflammation (C-reactive protein, CRP) and endothelial activation (thrombomodulin, vascular cell adhesion molecule-1, and von Willebrand factor) determined
- Measurements repeated in 52 patients after a follow-up of 32 ± 7 mos
- IMT increased in SLE patients compared to controls
- Prevalence of smoking and hypertension, use of lipid-lowering drugs and SCORE higher in patients, as well as levels of CRP and markers of endothelial activation
- Age-related increase in IMT significantly higher in patients than controls
- In multivariate analysis, age and disease duration independently related to IMT
- Increase in IMT during follow-up related to age only
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