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Antithrombotic and antiplatelet activities of fenofibrate, a lipid-lowering drug
Atherosclerosis, 10/07/09
Lee JJ et al. – The authors demonstrate that fenofibrate can significantly inhibit artery thrombus formation in vivo, which may be due to antiplatelet activity via the inhibition of thromboxane A2 receptor, cytosolic calcium mobilization and COX–1 activity, and the beneficial effect of fenofibrate on cardiovascular system may be also due to its modulation of platelet activation.
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