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Critical role of nociceptor plasticity in chronic pain
Trends in Neurosciences, 10/02/09

Reichling DB et al. – The transition from acute to chronic pain states might be the most important challenge in research to improve clinical treatment of debilitating pain. The authors describe a recently identified mechanism of neuronal plasticity in primary afferent nociceptive nerve fibers (nociceptors) by which an acute inflammatory insult or environmental stressor can trigger long–lasting hypersensitivity of nociceptors to inflammatory cytokines. This phenomenon, “hyperalgesic priming,” depends on the epsilon isoform of protein kinase C (PKC?) and a switch in intracellular signaling pathways that mediate cytokine–induced nociceptor hyperexcitability. The authors discuss the impact of this discovery on our understanding of, and ultimately our ability to treat, a variety of enigmatic and debilitating pain conditions, including those associated with repetitive injury, and generalized pain conditions, such as fibromyalgia.

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Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion
Pain, 11/02/09 Relevance Score: 68%

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain
Bone, 10/16/09 Relevance Score: 68%

Cervical lateral glide increases nociceptive flexion reflex threshold but not pressure or thermal pain thresholds in chronic whiplash associated disorders: A pilot randomised controlled trial
Manual Therapy, 11/03/09 Relevance Score: 67%

Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
Pain, 11/17/09 Relevance Score: 66%

Opiate-induced hypernociception and chemokine receptors
Neuropharmacology, 11/10/09 Relevance Score: 66%