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See Latest ArticlesThe Effect of Prescription Omega-3 Fatty Acids on Body Weight After 8 to 16 Weeks of Treatment for Very High Triglyceride Levels
Postgraduate Medicine, 09/30/09
Bays HE et al. – When coadministered with fenofibrate for up to 16 weeks, the modest daily caloric contribution of P–OM3 (Lovaza 4 g/day) did not alter body weight or waist circumference compared with baseline or compared with fenofibrate plus placebo in patients with very high triglyceride levels.
Methods- This analysis evaluated 167 dyslipidemic (triglycerides: >= 500 mg/dL and < 1300 mg/dL), overweight/obese (body mass index [BMI] >= 25 kg/m2 and <= 43 kg/m2) patients aged 18 to 79 years.
- Data were derived from an 8–week, randomized, double–blinded, placebo–controlled, parallel–group trial comparing P–OM3 4 g/day + fenofibrate 130 mg/day (n = 84) versus placebo (4 g/day of corn oil) + fenofibrate 130 mg/day (n = 83), and an 8–week open–label extension (n = 117), during which all subjects received P–OM3 + fenofibrate.
- Subjects who received P–OM3 + fenofibrate continued the same treatment in the extension phase (non–switchers; n = 59).
- Those who initially received corn oil placebo + fenofibrate received P–OM3 + fenofibrate in the extension phase (switchers; n = 58).
- During the 8–week double–blind phase in subjects receiving fenofibrate, the addition of P–OM3 (versus placebo) did not significantly change median (minimum, maximum) body weight or waist circumference.
- In the 8–week extension phase, non–switchers and switchers did not differ in median change from the end of the double–blind phase in body weight, or waist circumference.
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