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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
International Journal of Epidemiology, 09/25/09

Lips EH et al. – This study confirms the strong association between 15q gene variants and LC and shows an independent association with smoking quantity, as well as an association with UADT cancers.

Methods

The authors performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) with smoking behaviour and cancer risk in a total of 17 300 subjects from 5 lung cancer (LC) studies and 4 upper aerodigestive tract (UADT) cancer studies.

Results

Subjects with one minor allele smoked on average 0.3 cigarettes per day (CPD) more, whereas subjects with the homozygous minor AA genotype smoked on average 1.2 CPD more than subjects with a GG genotype.
The variant was associated with heavy smoking (>20 CPD).
The strong association between the variant and LC risk, was virtually unchanged after adjusting for this smoking association.
Furthermore, the authors found an association between the variant allele and an earlier age of LC onset.
The association was also noted in UADT cancers.
Genome wide association (GWA) analysis of over 300 000 SNPs on 11 219 subjects did not identify any additional variants related to smoking behaviour.