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Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study
Rheumatology, 09/28/09

Pertovaara M et al. – Our results indicate that ANA positivity is associated with decreased carotid elasticity in women, suggesting that mechanisms resulting in ANA production may be involved in the development of early atherosclerosis.

• 2278 participants in the Cardiovascular Risk in Young Finns Study
• ANAs examined by IIF using HEp-2 cells as substrate
• multivariate analyses
• Adjusted for age, BMI, serum concentrations of CRP, triglycerides, high-density lipoprotein and low-density lipoprotein cholesterol, blood pressure and smoking habits

• ANA positivity (titre > 160) was inversely associated (? = –0.145) with carotid compliance in women

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