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Ahsin S et al. – Neurobiological mechanisms invoking the release of endogenous opioids and depression of stress hormone release are believed to be the basis of acupuncture analgesia. This study compared plasma beta–endorphin and cortisol levels with self assessment scores of intensity of pain, before and after 10 days of electro–acupuncture treatment in patients suffering from chronic pain as a result of osteoarthritis knees...Electro–acupuncture resulted in an improvement in pain, stiffness and disability. Of clinical importance is that an improvement in objective measures of pain and stress/pain associated biomarkers was shown above that of a sham treatment; hence demonstrating acupuncture associated physiological changes beyond that of the placebo effects.

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