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See Latest ArticlesDifferential regulation of interleukin-17 and interferon-{gamma} production in inflammatory bowel disease
Gut, 09/22/09
Rovedatti L et al. – The authors findings support a role for IL–12, TGF–beta and IL–21 in modulating IL–17/IFN–gamma production in IBD. The abundant IL–17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti–IFN–gamma antibodies in clinical trials of Crohn’s disease.
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