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Akin I et al. – Aggressive diuresis carries a significant risk of electrolyte and volume depletion with subsequent arrhythmias, hypotension, and worsening renal function. Actually, little data from randomized clinical trials are available to guide therapeutic treatment with diuretics. Thus, the choice and dosing of diuretic therapy must be individualized based on general knowledge of potency and pharmacokinetic and pharmacodynamic considerations.

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