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Local lipopolysaccharide injection: A potential novel treatment for heterotopic ossification
Medical Hypotheses, 09/18/09

Xue DT et al. - Cell and molecular biology studies further found that LPS initiated the osteoclast formation, stimulated osteoclast activity and inhibited osteoblast differentiation. Given HO is an abnormality in bone modeling which increases bone mass within extraskeletal soft tissues, the authors herein hypothesize that local LPS injection might be a potential novel treatment for HO.

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HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage
Bone, 11/16/09 Relevance Score: 87%

HO-1 and CO Decrease Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cell Migration Via Inhibition of Nox1
Arteriosclerosis, Thrombosis, and Vascular Biology, 11/02/09 Relevance Score: 87%

Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock
Intensive Care Medicine, 10/20/09 Relevance Score: 87%

New $60 million research centre in Vancouver
Canadian Healthcare Technology, 10/26/09 Relevance Score: 84%

Risk of symptomatic heterotopic ossification following plate osteosynthesis in multiple trauma patients: an analysis in a level-1 trauma centre
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 10/14/09 Relevance Score: 84%