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LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
Cardiovascular Research, 09/16/09
Sugimoto K et al. – The present study provides evidence that the LOX–1–MT1–MMP axis plays a crucial role in RhoA and Rac1 activation signalling pathways in ox–LDL stimulation, suggesting that this axis may be a promising target for treating endothelial dysfunction.
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