Family Med

Your Article Summary

See Latest Articles

Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: a double-blind, parallel-group, randomized study
Cephalalgia, 09/04/09

Dahlof CH et al. – The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double–blind, placebo–controlled, multicentre, parallel–group study. Patients received 20 or 40 mg of tonabersat, or 50 mg of sumatriptan (positive control), or placebo at the onset of a moderate or severe attack. Headache intensity, relief and recurrence were recorded for 24 h after dosing. On the basis of primary or secondary efficacy measures, tonabersat did not provide a clinically or statistically significant advantage over placebo. Tonabersat generally was well tolerated and had no effect on vital signs, electrocardiogram recordings or laboratory values. The lack of efficacy may be a function of the slow absorption of tonabersat. As a consequence of slow absorption, daily administration of tonabersat as prophylaxis for migraine attacks is under investigation in ongoing studies.

Related Articles

See all related articles

Topiramate in migraine progression
The Journal of Headache and Pain, 10/21/09    Relevance Score: 96%

CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine
Expert Review of Neurotherapeutics, 11/12/09    Relevance Score: 94%

Aura migraines : Aura migraines double stroke risk
Internet Source, 11/02/09    Relevance Score: 94%

Migraine Chronification - Concept and Risk Factors
Discovery Medicine, 10/27/09    Relevance Score: 94%

Normal Cortical Energy Metabolism in Migrainous Stroke. A 31P-MR Spectroscopy Study
Stroke, 10/20/09    Relevance Score: 94%

Today in Clinical Pharmacology...keeping you current

Receive free subspecialty "5-minute updates" via email

Pharmacist and physician collaborative prescribing: For medication renewals within a primary health centre
Canadian Family Physician, 12/16/09

Collaboration between family physicians and community pharmacists to enhance adherence to chronic medications: Opinions of Saskatchewan family physicians
Canadian Family Physician, 12/16/09

Taking the stress out of managing gout
Canadian Family Physician, 12/16/09

 See all of Clinical Pharmacology

Today in Critical Care/Emergency...keeping you current

Receive free subspecialty "5-minute updates" via email

Continuous Deep Sedation Until Death: Palliation or Physician-Assisted Death?
American Journal of Hospice and Palliative Medicine, 12/16/09

Usefulness of Fragmented QRS on a 12-Lead Electrocardiogram in Acute Coronary Syndrome for Predicting Mortality
The American Journal of Cardiology, 12/16/09

Relation of Nausea and Vomiting in Acute Myocardial Infarction to Location of the Infarct
The American Journal of Cardiology, 12/16/09

 See all of Critical Care/Emergency