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Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers
Geriatrics and Gerontology International, 08/31/09
Fukai S et al. – Age was negatively associated with free testosterone and DHEA–S but not with total testosterone, while the 5–year changes of free testosterone and DHEA–S levels were not significant and showed no associations with major cardiovascular risk factors. Cross–sectionally, after adjustment for age, linear regression analysis showed a positive association between free testosterone and blood hemoglobin and a negative association between total testosterone and serum uric acid. In Japanese middle–aged men, 5–year androgen decline is too subtle to detect, and endogenous androgen levels seem to have relatively weak association with cardiovascular risk profiles.
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