Family Med Medical News about osteoarthritis;glucosamine;ibuprofen;cartilage turnover;physical training

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Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training
Osteoarthritis and Cartilage , 08/31/09

Petersen SG et al. – Serum COMP decreased significantly over the 12-week training period when treatment with glucosamine was added to the training regimen.

Methods

12 week double-blind, placebo-controlled, randomized study
36 elderly patients with bilateral tibiofemoral knee OA randomly assigned to tx with glucosamine, ibuprofen, or placebo during 12 weeks of strength training of both legs
Serum COMP and urinary CTX-II were measured by ELISA

Results

All 3 groups increased their muscle strength following 12 weeks of strength training
Serum COMP levels were reduced in the glucosamine-treated group after the training period, but did not change in the other 2 groups
Glucosamine reduced COMP compared to both placebo and ibuprofen
The mean reduction with glucosamine was 13% vs. placebo and 17% vs. ibuprofen

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