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Acute exercise and impaired glucose tolerance in obese humans
Journal of Clinical Lipidology, 08/19/09

McClean CM et al. – Findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with impaired glucose tolerance (IGT) by possibly improving glucose metabolism, independent of changes in oxidative stress.

• Study of the effects of acute aerobic exercise on glycemia, regional arterial stiffness, and oxidative stress in obese subjects with IGT
• Subjects: 12 obese pts; 7 men/5 women; 48.0±9.4 yrs; body mass index 32.4±7.0kg/m2) with IGT
• Test: 30-min walking at 65% of maximum predicted heart rate
• Pulse wave velocity (PWV) for determination of arterial stiffness
• Blood pressure monitoring before/after exercise, protein
• Venous blood samples drawn for glucose, blood lipids, and indices of oxidative stress and inflammation: lipid hydroperoxides; superoxide dismutase; high-sensitivity C-reactive

• Decreased values after exercise: PWV (9.1±1.2m/s vs 8.6±1.0m/s), glucose (5.7±0.6 mmol·L-1 vs. 5.4±0.6 mmol·L-1), and diastolic blood pressure (94±14mm Hg vs 86±13mm Hg), respectively
• Correlation between PWV and glucose
• No changes in lipid hydroperoxides, superoxide dismutase, high-sensitivity C-reactive protein, or blood lipids

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