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See Latest ArticlesEarly vasoactive drugs improve heart failure outcomes
Congestive Heart Failure, 08/14/09
Peacock WF et al. – Early vasoactive initiation is associated with improved outcomes in pts hospitalized for acute decompensated heart failure (ADHF).
Methods- Study of whether clinical outcomes are temporally associated with time to vasoactive therapy (vasoactive time) in ADHF
- Review of the Acute Decompensated Heart Failure (ADHERE) Registry
- Evaluation of the relationship between vasoactive time and inpatient mortality within 48 hrs of hospitalization
- Early use defined as <6 hrs
- Early use of vasoactive agents in 22,788 pts (63.8%); late use in 12,912 (36.2%)
- Median vasoactive time: 1.7 vs 14.7 hrs in early vs late groups
- In-hospital mortality significantly lower in early group
- Adjusted odds of death increased 6.8% for every 6 hrs of treatment delay
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