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See Latest ArticlesAnnual screening for prostate cancer did not reduce mortality from prostate cancer
Evidence-Based Medicine, 08/19/09
Canfield SE – In men 55–74 years of age, annual screening with prostate–specific antigen testing and digital rectal examination did not reduce mortality from prostate cancer.
Methods- Randomised controlled trial
- Participants: 76 693 men 55–74 years of age. Exclusion criteria included history of PLCO cancer, current cancer treatment, and >1 prostate–specific antigen (PSA) test in <=3 years in 10 centres in the USA.
- Annual screening with PSA testing for 6 years and digital rectal examination for 4 years (n = 38 343) or usual care that might include screening (n = 38 350).
- A serum PSA concentration >4.0 ng/ml was considered to be a positive result.
- Men and their primary physicians were informed of test results; they decided on further diagnostic evaluation and treatment, according to standard practice.
- In the screening group, compliance was 85% for PSA testing and 86% for digital rectal examination.
- In the control group, the rate of PSA testing increased over time from 40% to 52%; the rate of digital rectal examination was 41–46%.
- At 7 years, more men in the screening group had been diagnosed with prostate cancer, but groups did not differ for prostate cancer mortality.
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