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Prognostic interactions between statins and in-hospital revascularisation on the outcome of acute coronary syndrome
Heart, Lung, and Circulation, 08/03/09

Wong CK et al. – Both in-hospital revascularization and statin use at hospital discharge independently improved outcome over 2–5 yrs follow-up. No prognostic interaction was noted between these 2 beneficial therapies.

Methods

Study of whether statin use at initial hospital discharge influences the prognostic benefit of in-hospital revascularization on survival among pts with acute coronary syndrome (ACS)
Assessment of all ACS survivors discharged from 2 coronary care units between 2000-2002

Results

Of 1057 hospital survivors with ACS, 481 (45.5%) had in-hospital revascularization: CABG in 123 pts; PCI in 377; both procedures in 19
Statins prescribed at discharge in 47% of pts without and 73% of pts with revascularization
Revascularization associated with lower mortality up to 5 yrs of follow-up
Hazard ratio after adjusting for baseline differences and statin use: 0.39
Statin use was predictor for long-term survival
No significant interaction between statin use and in-hospital revascularization in predicting survival

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