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Testosterone and Depression: Systematic Review and Meta-Analysis
Journal of Psychiatric Practice, 07/27/09

TT may have an antidepressant effect in depressed patients, especially those with hypogonadism or HIV/AIDS and elderly subpopulations. The route by which TT is administered may play a role in treatment response.

Methods

Study source, total number of participants in the study and in each treatment group, participants' ages, number of participants with a diagnosis of hypogonadism or HIV/AIDS, study duration, type of intervention, and change in HAM–D scores in the groups receiving TT versus placebo.
The meta–analysis evaluated the effect of TT replacement on response in depressed patients as measured by change in HAM–D scores in the available placebo–controlled, randomized clinical trails.

Results

Seven studies (N=364) were identified that included a placebo–control group in a double–blind design.
Eligibility criteria were clearly reported in all trials.
Meta–analysis of the data from these seven studies showed a significant positive effect of TT therapy on HAM–D response in depressed patients when compared with placebo (z=4.04, P<0.0001).
Subgroup analysis also showed a significant response in the subpopulations with hypogonadism (z=3.84, P=0.0001) and HIV/AIDS (z=3.33, P=0.0009) as well as in patients treated with TT gel (z=2.32, P=0.02).

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