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Genetics: Prostate cancer
Canadian Family Physician, 07/15/09

Blaine SM et al. - The genetic basis of prostate cancer is complex and there are likely many different genes that modify risk. A major prostate cancer susceptibility gene has not yet been identified, but areas in the genome that might harbour prostate cancer–related genes are being investigated. Several studies show that 3 adjacent regions on chromosome 8 are associated with increased prostate cancer risk. One study concluded that 8% of prostate cancer in men of European ancestry and 16% of prostate cancer in men of African ancestry might be associated with a specific gene variant in these regions. None of the candidate genes is individually associated with a high risk of prostate cancer predisposition. It is likely that multiple genes contribute to the risk. At present, clinical genetic testing for inherited prostate cancer susceptibility is not available.

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