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52-Week Treatment with Diet and Exercise Plus Transdermal Testosterone Reverses the Metabolic Syndrome and Improves Glycaemic Control in Men with Newly Diagnosed Type 2 Diabetes and Subnormal Plasma Testosterone
Journal of Andrology, 07/09/09
Heufelder AE et al. - Men with the metabolic syndrome (MetS) and type 2 diabetes (T2D) often have low testosterone levels. Elevating low testosterone levels may improve features of the MetS and glycemic control. Addition of testosterone to supervised D&E results in greater therapeutic improvements of glycaemic control and reverses the MetS after 52-weeks of treatment in hypogonadal patients with the MetS and newly diagnosed T2D.
Louis J Gooren , 07/10/09
| There is a worldwide sex difference in cardiovascular disease favroring women over men and the classical reflex of physicians has traditionally been to ascribe this to the negative effects of testosterone on cardiovascualr health. The opposite could be true.Men with low levles of testosterone are at risk of the metabolic syndrome, cardiovascular disease and diabetes mellitus type 2. A pivotal question remains whether normalization of testosterone would be helpful in the treatment of diabetes mellitus. Our study showed that over and beyond the benefits of diet and exercise normalization of testosterone levels was a factor in a better metabolic control of diabetes mellitus and redressing the metabolic syndrome. |
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