Your Article Summary
See Latest ArticlesCochrane Musculoskeletal Group review: Acute gout
The Journal of Family Practice, 07/02/09
Winzenberg T et al. - Gout afflicts about 2% of men over age 30 and women over age 50 and its prevalence appears to be increasing. Options for treating acute gout include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, and intra-articular and systemic corticosteroids. Choosing among them can be challenging, however, because the evidence that one or another of these options yields real benefit is of varying strength. Using NSAIDs can be problematic with increasing age, as comorbidities like gastrointestinal (GI) bleeding, renal failure, heart failure, and cardiovascular risk increase and anticoagulant therapy is more likely to be in use. That’s where the kind of systematic reviews Cochrane Musculoskeletal Group (CMSG) performs can be of real help.
- Test your skills with 2 cases
- All 22 participants who took colchicine developed diarrhea or vomiting within 24 hours of initiating therapy
- One RCT found that oral prednisolone 35 mg daily and naproxen 500 mg twice daily were clinically equivalent
- NSAIDs are a reasonable first option, provided there are no contraindications
Related Articles
Outcome Domains for Studies of Acute and Chronic Gout
Journal of Rheumatology, 10/20/09
Relevance Score: 69%
Progress in Measurement Instruments for Acute and Chronic Gout Studies
Journal of Rheumatology, 10/23/09
Relevance Score: 68%
The modern management of gout
Rheumatology, 10/08/09
Relevance Score: 66%
Acute chylous ascites mimicking acute appendicitis in a patient with pancreatitis
World Journal of Gastroenterology, 10/20/09
Relevance Score: 47%
Acute silent cerebral infarction in children with sickle cell anemia
Pediatric Blood & Cancer, 10/09/09
Relevance Score: 46%
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis
Anti-Cancer Drugs, 12/09/09
Developments in factor Xa inhibitors for the treatment of thromboembolic disorders
Medicinal Research Reviews, 12/09/09
Cyclooxygenase inhibitors: Scope of their use and development in cancer chemotherapy
Medicinal Research Reviews, 12/09/09
Today in Critical Care/Emergency...keeping you current
Receive free subspecialty "5-minute updates" via email
Paracetamol versus ibuprofen: A randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures
Emergency Medicine Australasia, 12/09/09
Review: the Ottawa Ankle rules are accurate for excluding fractures in acute blunt ankle/midfoot injury in children
Evidence-Based Medicine, 12/08/09
Review: 3 prediction rules, particularly ABCD, identify ED patients who can be discharged with low risk of stroke after TIA
Evidence-Based Medicine, 12/08/09
Today in General Medicine...keeping you current
Receive free subspecialty "5-minute updates" via email
The Association Between the Number of Prescription Medications and Incident Falls in a Multi-ethnic Population of Adult Type-2 Diabetes Patients: The Diabetes and Aging Study
Journal of General Internal Medicine, 12/09/09
Can vitamin D intake assist in improving the outcome of endodontic treatment for diabetic patients?
Medical Hypotheses, 12/09/09
Characteristics of sick-listing cases that physicians consider problematic - analyses of written case reports
Scandinavian Journal of Primary Health Care, 12/09/09