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Prescribing statins to patients with nonalcoholic fatty liver disease: Real cardiovascular benefits outweigh theoretical hepatotoxic risk
Cardiovascular Drug Reviews, 06/26/09
Riley P et al. – A review summarizes the evidence for and against the prescription of statins to pts with nonalcoholic fatty liver disease, a group typically associated with high cardiovascular risk.
Methods- Review of evidence for/against statin use in nonalcoholic fatty liver disease
- Statins are widely prescribed, with a significant role in reducing cardiovascular risk
- Concern for hepatic safety profile may prevent use for pts with concurrent liver pathology
- Contrary to current opinion, considerable evidence for and little evidence against prescription of statins to this population
- Guidelines advising against statin use in this setting should be reviewed
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Effects of prescription omega-3-acid ethyl esters on lipoprotein particle concentrations, apolipoproteins AI and CIII, and lipoprotein-associated phospholipase A2 mass in statin-treated subjects with hypertriglyceridemia
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