Your Article Summary
See Latest ArticlesIncreased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: A novel pleiotropic effect of statins?
Cardiovascular Drugs and Therapy, 07/02/09
Yavuz B et al. – Findings show an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This result may reflect an important pleiotropic effect in which rosuvastatin reduces mortality in pts with coronary artery disease.
Methods- Prospective cohort study of the possible effect of rosuvastatin on vitamin D metabolism
- Subjects: 91 hyperlipidemic pts not previously treated with lipid lowering medications
- Assessment of lipid parameters, 25 hydroxyvitamin-D, 1,25-dihydroxyvitamin D, and bone alkaline phosphatase at baseline and after 8 wks of rosuvastatin treatment
- No study withdrawals due to adverse effects
- Mean pt age: 59.9±12.5 yrs; most pts male (55, 60%)
- Diabetes in 17 pts; systemic hypertension in 43 pts
- Significant increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7–67) to mean 36.3 (range 3.8–117) ng/mL)
- Increase of 1,25-dihydroxyvitamin D from mean 22.9±11.2 to 26.6±9.3 pg/dL
- Bone alkaline phosphatase decreased after 8 wks of rosuvastatin treatment, mean 17.7 (range 2.6–214) to mean 9.5 (range 2.3–19.1) u/L rosuvastatin treatment
Related Articles
25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus
Arthritis Care and Research, 10/01/09
Relevance Score: 72%
Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
British Medical Journal, 10/09/09
Relevance Score: 71%
Recognition and Management of Vitamin D Deficiency
American Family Physician, 10/19/09
Relevance Score: 70%
Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D
Pediatrics, 10/30/09
Relevance Score: 69%
Serum 25(OH)D Levels Modulate the Acute Phase Response Associated to the First Nitrogen Containing Bisphosphonate Infusion
Journal of Bone and Mineral Research, 10/02/09
Relevance Score: 69%
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Comparison of the efficacy of administering a combination of ezetimibe plus fenofibrate versus atorvastatin monotherapy in the treatment of dyslipidemia
Lipids in Health and Disease, 12/20/09
Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study
Age and Aging, 12/20/09
Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review
The American Journal of Geriatric Pharmacotherapy, 12/20/09