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Neurobiology of repeated transcranial magnetic stimulation in the treatment of anxiety: a critical review
International Clinical Psychopharmacology, 07/01/09

Pallanti S et al. - TMS remains an investigational intervention that has not yet gained approval for the clinical treatment of any anxiety disorder. Clinical sham-controlled trials are scarce. Many of these trials have supported the idea that TMS has a significant effect, but in some studies, the effect is small and short lived. The neurobiological correlates suggest possible efficacy for the treatment of social anxiety that still has to be investigated.

Methods

Searched Medline, PsycInfo, and the Cochrane Library from 1980 to January 2009 for the terms 'generalized anxiety disorder', 'social anxiety disorder', 'social phobia', 'panic', 'anxiety', or 'posttraumatic stress disorder' in combination with 'TMS', 'cortex excitability', 'rTMS', 'motor threshold', 'motor evoked potential', 'cortical silent period', 'intracortical inhibition', 'neuroimaging', or 'intracortical facilitation'.

Results

Most of the therapeutic experiences with repetitive TMS available in the literature are in the form of case reports, not controlled or blinded studies.
Stimulation of the right dorsolateral prefrontal cortex, especially at high frequencies, has been reported to reduce anxiety symptoms in posttraumatic stress disorder and panic disorder; nevertheless, results are mixed.
A specific role for the right dorsolateral prefrontal cortex in the posttraumatic stress disorder symptom core can be hypothesized.

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Effect of Repetitive Transcranial Magnetic Stimulation Over the Hand Motor Cortical Area on Central Pain After Spinal Cord Injury
Archives of Physical Medicine and Rehabilitation, 10/06/09 Relevance Score: 82%

Repetitive transcranial magnetic stimulation over bilateral hemispheres enhances motor function and training effect of paretic hand in patients after stroke
Journal of Rehabilitation Medicine, 11/16/09 Relevance Score: 81%

Repetitive transcranial magnetic stimulation or transcranial direct current stimulation
Brain Stimulation, 10/28/09 Relevance Score: 81%

Diffuse analgesic effects of unilateral repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers
Pain, 10/13/09 Relevance Score: 81%

Repetitive transcranial magnetic stimulation in patients with progressive supranuclear palsy: a pilot study
Acta Neurologica Belgica, 10/21/09 Relevance Score: 80%