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Noninvasive assessment of impaired endothelial function in psoriasis
Rheumatology International, 06/30/09

Ulusoy RE et al. – Study demonstrates that noninvasive methods such as ultrasonography, saving time and cost-effective, can be utilized for following outpatient psoriasis disease (PD) patients for the risk of endothelial dysfunction (ED), which may preclude to atherosclerosis.

• Main objectives of this study were:
  • Noninvasive assessment of endothelial dysfunction (ED) and
  • Diagnosing the possible early vascular development of atherosclerosis
    in psoriasis disease (PD)
• 28 PD pts (study group) w/o any obstructive vascular involvement, compared with 28 healthy controls (control group)
• Endothelium-independent dilation was assessed by measuring changes in brachial artery diameter following sublingual glyceryl trinitrate
• All pts underwent a complete transthoracic echocardiographic and tissue Doppler study
• A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease

• No difference between pts and controls in terms of echocardiographic and tissue Doppler parameters, and baseline brachial artery diameters
• Flow-mediated dilation showed 37% impairment in study group vs control
• Endothelium-independent NTG dilatation did not differ in both groups

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