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Noninvasive assessment of impaired endothelial function in psoriasis
Rheumatology International, 06/30/09

Ulusoy RE et al. – Study demonstrates that noninvasive methods such as ultrasonography, saving time and cost-effective, can be utilized for following outpatient psoriasis disease (PD) patients for the risk of endothelial dysfunction (ED), which may preclude to atherosclerosis.

Methods

Main objectives of this study were:
- Noninvasive assessment of endothelial dysfunction (ED) and
- Diagnosing the possible early vascular development of atherosclerosis
  in psoriasis disease (PD)
28 PD pts (study group) w/o any obstructive vascular involvement, compared with 28 healthy controls (control group)
Endothelium-independent dilation was assessed by measuring changes in brachial artery diameter following sublingual glyceryl trinitrate
All pts underwent a complete transthoracic echocardiographic and tissue Doppler study
A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease

Results

No difference between pts and controls in terms of echocardiographic and tissue Doppler parameters, and baseline brachial artery diameters
Flow-mediated dilation showed 37% impairment in study group vs control
Endothelium-independent NTG dilatation did not differ in both groups

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