Family Med

Your Article Summary

See Latest Articles

Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: A prospective cohort study
The Lancet Neurology, 06/29/09

Visser PJ et al. – Alzheimer's disease (AD) is a common cause of subjective cognitive impairment (SCI), non-amnestic mild CI (naMCI), and amnestic mild CI (aMCI) and is associated with cognitive decline in pts with naMCI or aMCI. Pts with SCI may be in early-stage AD, and cognitive decline might become apparent only after longer follow-up.

• Study of the prevalence of a CSF AD profile in pts with SCI, naMCI, or aMCI
• Investigation of the association of this profile with cognitive outcome in each group
• Prospective cohort study of pts with SCI, naMCI, aMCI, and neurologically healthy controls from 20 European memory clinics January 2003-June 2005
• CSF AD profile defined as an abnormal ratio of Abeta42:tau
• Annual assessment of pts up to 3 yrs
• Outcome measures: changes in memory, overall cognition, Mini-Mental State Examination (MMSE) score, daily function, and progression to AD-type dementia

• CSF AD profile more common in pts with SCI (31/60 [52%]), naMCI (25/37 [68%]), and aMCI (56/71 [79%]) vs healthy controls (28 of 89 [31%])
• Profile associated with cognitive decline in naMCI pts (memory, MMSE, daily function) and in aMCI pts (MMSE, daily function)
• In aMCI pts, CSF AD profile predictive of AD-type dementia

Today in Geriatrics...keeping you current

Receive free subspecialty "5-minute updates" via email

Acute medical management of the non-ST-segment elevation acute coronary syndromes (NSTE-ACS) in older patients
Archives of Gerontology and Geriatrics, 10/13/09

Approach to Thrombocytopenia in Older Adults
Geriatrics & Aging, 11/10/09

Vitamin D insufficiency and health outcomes over 5 y in older women
American Journal of Clinical Nutrition, 11/13/09

See All of Geriatrics