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See Latest ArticlesThe role of cigarette smoking and statins in the development of postmenopausal osteoporosis: A pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort
Osteoporosis International, 06/15/09
Giampietro PF et al. – Study provides evidence for a role of genetic variation in interleukin 6 (IL6) and lipoprotein receptor-related protein 5 (LRP5) in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers.
Methods- Aim was to assess the relative impact of cigarette smoking, statin use, genetic polymorphisms, and one-way interaction of these factors on development of osteoporosis in postmenopausal women
- Genotyping of 14 SNPs corresponding to:
- vit D receptor gene, estrogen receptor 1,
- collagen type 1 alpha 1, IL6, transcription growth factor beta,
- apolipoprotein E, and LRP5 genes
was performed in cases (n=309) with osteoporosis and controls (n=293) with normal BMD drawn from a homogeneous Caucasian population
- SNPs were chosen based on known functional consequences or prior evidence
- They were genotyped using matrix-assisted laser desorption ionization time-of-flight technology (MALDI TOF)
- Cases differed from controls relative to BMI, age, and smoking but not statin use
- After adjusting for age, the IL6 -634G>C (rs1800796) allele showed association with osteoporosis, independent of statin use or smoking status
- On stratification for smoking, association with LRP5 C135242T (rs545382) and osteoporosis emerged, suggestive of potential environmental interaction
Philip F. Giampietro, 06/15/09
| Replication of the LRP5 results in a different population would be important to verify interaction between LRP5 C135242T (rs545382) and cigarette smoking. Future prevention methods aimed at targeting individuals with this genotype who are smokers or potential smokers could be piloted. |
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