Family Med

Your Article Summary

The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: A pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort
Osteoporosis International, 06/15/09

Giampietro PF et al. – Study provides evidence for a role of genetic variation in interleukin 6 (IL6) and lipoprotein receptor-related protein 5 (LRP5) in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers.

Methods

• Aim was to assess the relative impact of cigarette smoking, statin use, genetic polymorphisms, and one-way interaction of these factors on development of osteoporosis in postmenopausal women
• Genotyping of 14 SNPs corresponding to:
  • vit D receptor gene, estrogen receptor 1,
  • collagen type 1 alpha 1, IL6, transcription growth factor beta,
  • apolipoprotein E, and LRP5 genes
    was performed in cases (n=309) with osteoporosis and controls (n=293) with normal BMD drawn from a homogeneous Caucasian population
• SNPs were chosen based on known functional consequences or prior evidence
• They were genotyped using matrix-assisted laser desorption ionization time-of-flight technology (MALDI TOF)

Results

• Cases differed from controls relative to BMI, age, and smoking but not statin use
• After adjusting for age, the IL6 -634G>C (rs1800796) allele showed association with osteoporosis, independent of statin use or smoking status
• On stratification for smoking, association with LRP5 C135242T (rs545382) and osteoporosis emerged, suggestive of potential environmental interaction

<< Previous Are Adolescents Being Screened for Emotional Distress in Primary...

Next >> Community pharmacist-initiated screening program for...