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Use of aripiprazole in tardive dyskinesia: An open label study of six cases
World Journal of Biological Psychiatry, 06/10/09

Rajarethinam R et al. - The study supports our hypothesis that clinically stable patients with moderate tardive dyskinesia who are under treatment with other first- or second-generation antipsychotics may benefit from switching to aripiprazole with a reduction of TD symptoms but with out any significant benefit in psychiatric symptoms.

Methods

Six clinically stable patients with schizophrenia or Schizoaffective disorder and a moderate to severe TD participated in this study.
They were systematically cross-titrated from their current medication to aripiprazole and maintained for 16 weeks.

Results

The mean extra pyramidal symptom score measured by Abnormal Involuntary Movement Scale (AIMS) improved from a baseline score of 15.8 to final score of 5 (paired t-test; P=0.0009).
The severity of psychiatric symptoms remained unchanged

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