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Association between circulating osteoprogenitor cell numbers and bone mineral density in postmenopausal osteoporosis
Osteoporosis International, 06/12/09

Pirro M et al. – Study reports that in postmenopausal osteoporotic women, a reduced number of circulating AP+ cells and increased levels of AP+/CD34+, OCN+, and OCN+/CD34+ cells are associated with reduced bone mineral density (BMD).

Methods

Aim was to investigate if an association exists between the number of circulating osteoprogenitor cells and BMD in postmenopausal women with and w/o osteoporosis
Number of circulating AP+, osteocalcin-positive (OCN+), AP+/CD34+, and OCN+/CD34+ cells was quantified in 54 postmenopausal osteoporotic women and 36 age-matched nonosteoporotic controls

Results

Number of AP+ cells was lower in osteoporotic women
Higher levels of AP+/CD34+, OCN+, and OCN+/CD34+ cells were found in osteoporotic than controls
Number of AP+ cells was correlated with lumbar BMD and proximal femur BMD
Whereas inverse correlations were found between AP+/CD34+ cells, OCN+, OCN+/CD34+, and BMD
Reduced AP+ cells and increased AP+/CD34?+, OCN+, and OCN+/CD34+ cells were predictors of low BMD, independent of traditional risk factors for osteoporosis

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